If anything happens, don't expect changes to the ride system. The standard winter maintenance on the ride has already commenced, which means that the ride system will return.
I am under the impression that the Derren IP was originally 6 years long, which would mean it would expire this year. There were some unknowns there, with the ride having opened late in 2016, and not opening at all in 2020. But I imagine its in both parties interests to just wrap things up with it and move on.
The thing with Ghost Train is it would be very easy to remove Derren from it. Replace the pre show and edit his voice out of the start / end of the VR. Stick a different video in the finale, if they even keep that, and boom, done. Just drop the 'Derren Brown's' part of the name. Very easy, very cheap.
Given the state of the VR headsets and the general mess they are though, it would make sense for them to attempt to do more. New VR. The long-suggested have screens in the windows instead. Have it as a completely actor led experience, turning it into a more Dungeons-esque experience. There's lots of more costly options there if they choose to do anything substantial to it.